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NR1D2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14995
Clone Names 100517169
Peptide ID 100517169
Additional Information
Gene ID 9975
Other Names Nuclear receptor subfamily 1 group D member 2, Orphan nuclear hormone receptor BD73, Rev-erb alpha-related receptor, RVR, Rev-erb-beta, V-erbA-related protein 1-related, EAR-1R, NR1D2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR1D2
Function Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}
Tissue Location Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues
Research Areas
Citations (0)

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This gene encodes a member of the nuclear hormone receptorfamily, specifically the NR1 subfamily of receptors. The encodedprotein functions as a transcriptional repressor and may play arole in circadian rhythms and carbohydrate and lipid metabolism.Alternatively spliced transcript variants have been described.


Campos-de-Sousa, S., et al. J. Biol. Rhythms 25(2):132-137(2010)Burris, T.P. Mol. Endocrinol. 22(7):1509-1520(2008)Liu, A.C., et al. PLoS Genet. 4 (2), E1000023 (2008) :Wang, J., et al. Biochim. Biophys. Acta 1783(2):224-236(2008)Raghuram, S., et al. Nat. Struct. Mol. Biol. 14(12):1207-1213(2007)

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$ 80.00
Cat# BP14855c
Availability: In Stock
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