GLP2R Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95838 |
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Clone Names | 100517188 |
Gene ID | 9340 |
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Other Names | Glucagon-like peptide 2 receptor, GLP-2 receptor, GLP-2-R, GLP-2R, GLP2R |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GLP2R |
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Function | This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The GLP2 receptor (GLP2R) is a G protein-coupled receptorsuperfamily member closely related to the glucagon receptor ansGLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acidproglucagon-derived peptide produced by intestinal enteroendocrinecells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, itis derived from the proglucagon peptide encoded by the GCG gene.GLP2 stimulates intestinal growth and upregulates villus height inthe small intestine, concomitant with increased crypt cellproliferation and decreased enterocyte apoptosis. Moreover, GLP2prevents intestinal hypoplasia resulting from total parenteralnutrition. GLP2R, a G protein-coupled receptor superfamily memberis expressed in the gut and closely related to the glucagonreceptor (GCGR) and the receptor for GLP1 (GLP1R). [provided byRefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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