|Other Names||Glucagon-like peptide 2 receptor, GLP-2 receptor, GLP-2-R, GLP-2R, GLP2R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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The GLP2 receptor (GLP2R) is a G protein-coupled receptorsuperfamily member closely related to the glucagon receptor ansGLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acidproglucagon-derived peptide produced by intestinal enteroendocrinecells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, itis derived from the proglucagon peptide encoded by the GCG gene.GLP2 stimulates intestinal growth and upregulates villus height inthe small intestine, concomitant with increased crypt cellproliferation and decreased enterocyte apoptosis. Moreover, GLP2prevents intestinal hypoplasia resulting from total parenteralnutrition. GLP2R, a G protein-coupled receptor superfamily memberis expressed in the gut and closely related to the glucagonreceptor (GCGR) and the receptor for GLP1 (GLP1R). [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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