|Other Names||Stanniocalcin-1, STC-1, STC1, STC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.|
|Tissue Location||Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla|
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This gene encodes a secreted, homodimeric glycoproteinthat is expressed in a wide variety of tissues and may haveautocrine or paracrine functions. The gene contains a 5' UTR richin CAG trinucleotide repeats. The encoded protein contains 11conserved cysteine residues and is phosphorylated by protein kinaseC exclusively on its serine residues. The protein may play a rolein the regulation of renal and intestinal calcium and phosphatetransport, cell metabolism, or cellular calcium/phosphatehomeostasis. Overexpression of human stanniocalcin 1 in miceproduces high serum phosphate levels, dwarfism, and increasedmetabolic rate. This gene has altered expression in hepatocellular,ovarian, and breast cancers.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, G., et al. J. Natl. Cancer Inst. 102(11):812-827(2010)Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Trindade, D.M., et al. BMC Struct. Biol. 9, 57 (2009) :
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