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STC1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P52823
Clone Names 100517305
Additional Information
Gene ID 6781
Other Names Stanniocalcin-1, STC-1, STC1, STC
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STC1
Synonyms STC
Function Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Cellular Location Secreted.
Tissue Location Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla
Research Areas
Citations (0)
citation

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Background

This gene encodes a secreted, homodimeric glycoproteinthat is expressed in a wide variety of tissues and may haveautocrine or paracrine functions. The gene contains a 5' UTR richin CAG trinucleotide repeats. The encoded protein contains 11conserved cysteine residues and is phosphorylated by protein kinaseC exclusively on its serine residues. The protein may play a rolein the regulation of renal and intestinal calcium and phosphatetransport, cell metabolism, or cellular calcium/phosphatehomeostasis. Overexpression of human stanniocalcin 1 in miceproduces high serum phosphate levels, dwarfism, and increasedmetabolic rate. This gene has altered expression in hepatocellular,ovarian, and breast cancers.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, G., et al. J. Natl. Cancer Inst. 102(11):812-827(2010)Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Trindade, D.M., et al. BMC Struct. Biol. 9, 57 (2009) :

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$ 277.78
Cat# BP14863b
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