FDPS Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P14324 |
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Clone Names | 100517306 |
Gene ID | 2224 |
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Other Names | Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FDPS (HGNC:3631) |
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Synonyms | FPS, KIAA1293 |
Function | Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that catalyzes the productionof geranyl pyrophosphate and farnesyl pyrophosphate fromisopentenyl pyrophosphate and dimethylallyl pyrophosphate. Theresulting product, farnesyl pyrophosphate, is a key intermediate incholesterol and sterol biosynthesis, a substrate for proteinfarnesylation and geranylgeranylation, and a ligand or agonist forcertain hormone receptors and growth receptors. Drugs that inhibitthis enzyme prevent the post-translational modifications of smallGTPases and have been used to treat diseases related to boneresorption. Multiple pseudogenes have been found on chromosomes 1,7, 14, 15, 21 and X. Multiple transcript variants encodingdifferent isoforms have been found for this gene.
References
Ishimoto, K., et al. Biochem. J. 429(2):347-357(2010)Choi, H.J., et al. Yonsei Med. J. 51(2):231-238(2010)Li, J., et al. J. Immunol. 182(12):8118-8124(2009)Romanelli, M.G., et al. Genomics 93(3):227-234(2009)Marini, F., et al. Curr Med Res Opin 24(9):2609-2615(2008)
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