|Other Names||Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme that catalyzes the productionof geranyl pyrophosphate and farnesyl pyrophosphate fromisopentenyl pyrophosphate and dimethylallyl pyrophosphate. Theresulting product, farnesyl pyrophosphate, is a key intermediate incholesterol and sterol biosynthesis, a substrate for proteinfarnesylation and geranylgeranylation, and a ligand or agonist forcertain hormone receptors and growth receptors. Drugs that inhibitthis enzyme prevent the post-translational modifications of smallGTPases and have been used to treat diseases related to boneresorption. Multiple pseudogenes have been found on chromosomes 1,7, 14, 15, 21 and X. Multiple transcript variants encodingdifferent isoforms have been found for this gene.
Ishimoto, K., et al. Biochem. J. 429(2):347-357(2010)Choi, H.J., et al. Yonsei Med. J. 51(2):231-238(2010)Li, J., et al. J. Immunol. 182(12):8118-8124(2009)Romanelli, M.G., et al. Genomics 93(3):227-234(2009)Marini, F., et al. Curr Med Res Opin 24(9):2609-2615(2008)
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