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FDPS Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P14324
Clone Names 100517306
Peptide ID 100517306
Additional Information
Gene ID 2224
Other Names Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FPS, KIAA1293
Function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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This gene encodes an enzyme that catalyzes the productionof geranyl pyrophosphate and farnesyl pyrophosphate fromisopentenyl pyrophosphate and dimethylallyl pyrophosphate. Theresulting product, farnesyl pyrophosphate, is a key intermediate incholesterol and sterol biosynthesis, a substrate for proteinfarnesylation and geranylgeranylation, and a ligand or agonist forcertain hormone receptors and growth receptors. Drugs that inhibitthis enzyme prevent the post-translational modifications of smallGTPases and have been used to treat diseases related to boneresorption. Multiple pseudogenes have been found on chromosomes 1,7, 14, 15, 21 and X. Multiple transcript variants encodingdifferent isoforms have been found for this gene.


Ishimoto, K., et al. Biochem. J. 429(2):347-357(2010)Choi, H.J., et al. Yonsei Med. J. 51(2):231-238(2010)Li, J., et al. J. Immunol. 182(12):8118-8124(2009)Romanelli, M.G., et al. Genomics 93(3):227-234(2009)Marini, F., et al. Curr Med Res Opin 24(9):2609-2615(2008)

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$ 80.00
Cat# BP14864a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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