|Other Names||Thymidine kinase 2, mitochondrial, Mt-TK, TK2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.|
|Tissue Location||Predominantly expressed in liver, pancreas, muscle, and brain|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a deoxyribonucleoside kinase thatspecifically phosphorylates thymidine, deoxycytidine, anddeoxyuridine. The encoded enzyme localizes to the mitochondria andis required for mitochondrial DNA synthesis. Mutations in this geneare associated with a myopathic form of mitochondrial DNA depletionsyndrome. Alternate splicing results in multiple transcriptvariants.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Sato, N., et al. Am. J. Hum. Genet. 85(5):544-557(2009)Collins, J., et al. Neuromuscul. Disord. 19(11):784-787(2009)Villarroya, J., et al. Exp. Cell Res. 315(8):1429-1438(2009)Frangini, M., et al. FEBS J. 276(4):1104-1113(2009)
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