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TK2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O00142
Clone Names 100517309
Peptide ID 100517309
Additional Information
Gene ID 7084
Other Names Thymidine kinase 2, mitochondrial, Mt-TK, TK2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TK2
Function Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.
Cellular Location Mitochondrion.
Tissue Location Predominantly expressed in liver, pancreas, muscle, and brain
Research Areas
Citations (0)

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Background

This gene encodes a deoxyribonucleoside kinase thatspecifically phosphorylates thymidine, deoxycytidine, anddeoxyuridine. The encoded enzyme localizes to the mitochondria andis required for mitochondrial DNA synthesis. Mutations in this geneare associated with a myopathic form of mitochondrial DNA depletionsyndrome. Alternate splicing results in multiple transcriptvariants.

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)Sato, N., et al. Am. J. Hum. Genet. 85(5):544-557(2009)Collins, J., et al. Neuromuscul. Disord. 19(11):784-787(2009)Villarroya, J., et al. Exp. Cell Res. 315(8):1429-1438(2009)Frangini, M., et al. FEBS J. 276(4):1104-1113(2009)

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$ 80.00
Cat# BP14865b
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