|Other Names||LIM domain-binding protein 1, LDB-1, Carboxyl-terminal LIM domain-binding protein 2, CLIM-2, LIM domain-binding factor CLIM2, hLdb1, Nuclear LIM interactor, LDB1, CLIM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).|
|Tissue Location||Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.|
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LDB1 binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).
Howard, P.W., et al. Biochem. Biophys. Res. Commun. 396(3):674-678(2010)Howard, P.W., et al. Biochem. J. 429(1):127-136(2010)Bhati, M., et al. EMBO J. 27(14):2018-2029(2008)Ryan, D.P., et al. Proteins 70(4):1461-1474(2008)Tran, Y.H., et al. J. Biochem. 140(1):105-119(2006)
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