|Other Names||Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNB2, CACNLB2, MYSB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in all tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of a voltage-dependent calciumchannel protein which is a member of the voltage-gated calciumchannel superfamily. The gene product was originally identified asan antigen target in Lambert-Eaton myasthenic syndrome which is anautoimmune disorder. Mutations in this gene are associated withBrugada symdrome. Alternatively spliced variants have beenidentified for this gene.
Burashnikov, E., et al. Heart Rhythm (2010) In press :Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)Lee, M.T., et al. Mol. Psychiatry (2010) In press :
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