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CACNB2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q08289 |
|---|---|
| Clone Names | 100525262 |
| Gene ID | 783 |
|---|---|
| Other Names | Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNB2, CACNLB2, MYSB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CACNB2 |
|---|---|
| Synonyms | CACNLB2, MYSB |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). |
| Cellular Location | Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side |
| Tissue Location | Expressed in all tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a subunit of a voltage-dependent calciumchannel protein which is a member of the voltage-gated calciumchannel superfamily. The gene product was originally identified asan antigen target in Lambert-Eaton myasthenic syndrome which is anautoimmune disorder. Mutations in this gene are associated withBrugada symdrome. Alternatively spliced variants have beenidentified for this gene.
References
Burashnikov, E., et al. Heart Rhythm (2010) In press :Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)Lee, M.T., et al. Mol. Psychiatry (2010) In press :
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