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ARHGEF1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q92888
Clone Names 100525269
Peptide ID 100525269
Additional Information
Gene ID 9138
Other Names Rho guanine nucleotide exchange factor 1, 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub15, ARHGEF1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.
Cellular Location Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Rho GTPases play a fundamental role in numerous cellularprocesses that are initiated by extracellular stimuli that workthrough G protein coupled receptors. The encoded protein may formcomplex with G proteins and stimulate Rho-dependent signals.Multiple alternatively spliced transcript variants have been foundfor this gene, but the full-length nature of some variants has notbeen defined.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Loirand, G., et al. Med Sci (Paris) 26 (6-7), 561-563 (2010) :Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Slattum, G., et al. J. Cell Biol. 186(5):693-702(2009)

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$ 80.00
Cat# BP14869a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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