|Other Names||Rho guanine nucleotide exchange factor 1, 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub15, ARHGEF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.|
|Cellular Location||Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation|
|Tissue Location||Ubiquitously expressed.|
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Rho GTPases play a fundamental role in numerous cellularprocesses that are initiated by extracellular stimuli that workthrough G protein coupled receptors. The encoded protein may formcomplex with G proteins and stimulate Rho-dependent signals.Multiple alternatively spliced transcript variants have been foundfor this gene, but the full-length nature of some variants has notbeen defined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Loirand, G., et al. Med Sci (Paris) 26 (6-7), 561-563 (2010) :Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Slattum, G., et al. J. Cell Biol. 186(5):693-702(2009)
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