|Other Names||Origin recognition complex subunit 3, Origin recognition complex subunit Latheo, ORC3, LATHEO, ORC3L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.|
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The origin recognition complex (ORC) is a highly conservedsix subunits protein complex essential for the initiation of theDNA replication in eukaryotic cells. Studies in yeast demonstratedthat ORC binds specifically to origins of replication and serves asa platform for the assembly of additional initiation factors suchas Cdc6 and Mcm proteins. The protein encoded by this gene is asubunit of the ORC complex. Studies of a similar gene in Drosophilasuggested a possible role of this protein in neuronal proliferationand olfactory memory. Alternatively spliced transcript variantsencoding distinct isoforms have been reported for this gene.
Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)DeRosse, P., et al. Schizophr Bull 34(6):1047-1053(2008)Siddiqui, K., et al. J. Biol. Chem. 282(44):32370-32383(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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