|Other Names||Kell blood group glycoprotein, 3424-, CD238, KEL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton|
|Tissue Location||Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a type II transmembrane glycoproteinthat is the highly polymorphic Kell blood group antigen. The Kellglycoprotein links via a single disulfide bond to the XK membraneprotein that carries the Kx antigen. The encoded protein containssequence and structural similarity to members of the neprilysin(M13) family of zinc endopeptidases.
Di Cristofaro, J., et al. J Mol Diagn 12(4):453-460(2010)Boturao-Neto, E., et al. Transfusion 50(3):735-737(2010)Yang, Y., et al. Transfus Med 19(5):235-244(2009)Kormoczi, G.F., et al. Transfusion 49(4):733-739(2009)Lee, S., et al. Blood 102(8):3028-3034(2003)
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