|Other Names||Necdin, NDN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).|
|Cellular Location||Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix|
|Tissue Location||Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene is located in the Prader-Willisyndrome deletion region. It is an imprinted gene and is expressedexclusively from the paternal allele. Studies in mouse suggest thatthe protein encoded by this gene may suppress growth in postmitoticneurons.
Chapman, E.J., et al. Mol. Carcinog. 48(11):975-981(2009)Yoshikawa, K. No To Hattatsu 41(3):214-218(2009)Liu, X., et al. Mol. Cell. Neurosci. 41(1):51-61(2009)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Lau, J.C., et al. Nucleic Acids Res. 32(11):3376-3382(2004)
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