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GCNF (NR6A1) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15406
Clone Names 70716055
Peptide ID 70716055
Additional Information
Gene ID 2649
Other Names Nuclear receptor subfamily 6 group A member 1, Germ cell nuclear factor, GCNF, hGCNF, Retinoid receptor-related testis-specific receptor, RTR, hRTR, NR6A1, GCNF
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1487b was selected from the C-term region of human NR6A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR6A1
Synonyms GCNF
Function Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).
Cellular Location Nucleus.
Tissue Location Shows highest expression in the germ cells of the adult testis.
Research Areas
Citations (0)

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NR6A1 has been shown to affect gene expression in embryogenesis and spermatogenesis and is essential for embryonic survival and normal development. Loss of NR6A1 causes embryonic lethality and disrupts normal somitogenesis as well as neural-tube and axis formation. NR6A1 binds as a homodimer to the DR0 DNA response element and has been shown to regulate transcription of genes including protamines 1 and 2 and Oct4. NR6A1 repression function has been shown to be mediated by interaction with the co-repressors N-COR and SMRT in the absence of ligand.


Rajkovic,M., J. Biol. Chem. 279 (50), 52493-52499 (2004)

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$ 80.00
Cat# BP1487b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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