|Other Names||GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1, 2-mannosyltransferase, Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase, ALG11, GT8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain.|
|Cellular Location||Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein|
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This gene encodes aGDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase whichis localized to the cytosolic side of the endoplasmic reticulum(ER) and catalyzes the transfer of the fourth and fifth mannoseresidue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol andMan4GlcNAc2-PP-dolichol resulting in the production ofMan5GlcNAc2-PP-dolichol. Mutations in this gene are associated withcongenital disorder of glycosylation type Ip (CDGIP). This geneoverlaps but is distinct from the UTP14, U3 small nucleolarribonucleoprotein, homolog C (yeast) gene. A pseudogene of theGDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase hasbeen identified on chromosome 19.
Rind, N., et al. Hum. Mol. Genet. 19(8):1413-1424(2010)Rohozinski, J., et al. Biol. Reprod. 74(4):644-651(2006)
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