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HYAL1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q12794 |
|---|---|
| Clone Names | 100318023 |
| Gene ID | 3373 |
|---|---|
| Other Names | Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HYAL1 |
|---|---|
| Synonyms | LUCA1 |
| Function | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. |
| Cellular Location | Secreted. Lysosome |
| Tissue Location | Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a lysosomal hyaluronidase.Hyaluronidases intracellularly degrade hyaluronan, one of the majorglycosaminoglycans of the extracellular matrix. Hyaluronan isthought to be involved in cell proliferation, migration anddifferentiation. This enzyme is active at an acidic pH and is themajor hyaluronidase in plasma. Mutations in this gene areassociated with mucopolysaccharidosis type IX, or hyaluronidasedeficiency. The gene is one of several related genes in a region ofchromosome 3p21.3 associated with tumor suppression. Multipletranscript variants encoding different isoforms have been found forthis gene.
References
Lanktree, M.B., et al. Blood 116(12):2160-2163(2010)Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010)Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Wang, X.Y., et al. Chin. Med. J. 122(11):1300-1304(2009)
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