|Other Names||Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.|
|Cellular Location||Secreted. Lysosome|
|Tissue Location||Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a lysosomal hyaluronidase.Hyaluronidases intracellularly degrade hyaluronan, one of the majorglycosaminoglycans of the extracellular matrix. Hyaluronan isthought to be involved in cell proliferation, migration anddifferentiation. This enzyme is active at an acidic pH and is themajor hyaluronidase in plasma. Mutations in this gene areassociated with mucopolysaccharidosis type IX, or hyaluronidasedeficiency. The gene is one of several related genes in a region ofchromosome 3p21.3 associated with tumor suppression. Multipletranscript variants encoding different isoforms have been found forthis gene.
Lanktree, M.B., et al. Blood 116(12):2160-2163(2010)Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010)Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Wang, X.Y., et al. Chin. Med. J. 122(11):1300-1304(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.