|Other Names||Sal-like protein 4, Zinc finger protein 797, Zinc finger protein SALL4, SALL4, ZNF797|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1488b was selected from the C-term region of human SALL4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML).|
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Provided below are standard protocols that you may find useful for product applications.
Sall4 is a probable transcription factor. Defects in Sall4 are the cause of Okihiro syndrome; also known as Duane radial ray syndrome (DRRS). It is a disorder characterized by the association of forearm malformations with Duane retraction syndrome. Sall4 is also involved in forelimb and heart development in mice.
Borozdin,W., Hum. Mutat. 28 (8), 830 (2007)Yang,J., Proc. Natl. Acad. Sci. U.S.A. 104 (25), 10494-10499 (2007)Paradisi,I.,Am. J. Med. Genet. A 143 (4), 326-332 (2007)
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