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TRIM27 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P14373
Clone Names 100408315
Peptide ID 100408315
Additional Information
Gene ID 5987
Other Names Zinc finger protein RFP, 632-, RING finger protein 76, Ret finger protein, Tripartite motif-containing protein 27, TRIM27, RFP, RNF76
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM27
Synonyms RFP, RNF76
Function E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA.
Cellular Location Nucleus. Cytoplasm. Nucleus, PML body. Early endosome. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269|PubMed:23452853}
Tissue Location Expressed in testis namely within the seminiferous tubules.
Research Areas
Citations (0)

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This gene encodes a member of the tripartite motif (TRIM)family. The TRIM motif includes three zinc-binding domains, a RING,a B-box type 1 and a B-box type 2, and a coiled-coil region. Thisprotein localizes to the nuclear matrix. It interacts with theenhancer of polycomb protein and represses gene transcription. Itis also thought to be involved in the differentiation of male germcells. Fusion of the N-terminus of this protein with the truncatedC-terminus of the RET gene product has been shown to result inproduction of the ret transforming protein.


Johnson, A.D., et al. Nat. Genet. 42(7):608-613(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Tezel, G.G., et al. Pathol. Res. Pract. 205(6):403-408(2009)Li, X., et al. Virology 360(2):419-433(2007)Lim, J., et al. Cell 125(4):801-814(2006)

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$ 80.00
Cat# BP14892b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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