|Other Names||Neuroguidin, Centromere accumulated nuclear protein 1, CANu1, EIF4E-binding protein, NGDN, C14orf120|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage.|
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Provided below are standard protocols that you may find useful for product applications.
Neuroguidin is an EIF4E (MIM 133440)-binding protein thatinteracts with CPEB (MIM 607342) and functions as a translationalregulatory protein during development of the vertebrate nervoussystem (Jung et al., 2006 [PubMed 16705177]).
Sihn, C.R., et al. Genes Cells 13(8):787-796(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Jung, M.Y., et al. Mol. Cell. Biol. 26(11):4277-4287(2006)Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
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