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NGDN Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NEJ9 |
|---|---|
| Clone Names | 100416022 |
| Gene ID | 25983 |
|---|---|
| Other Names | Neuroguidin, Centromere accumulated nuclear protein 1, CANu1, EIF4E-binding protein, NGDN, C14orf120 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NGDN (HGNC:20271) |
|---|---|
| Synonyms | C14orf120 |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9DB96}. Nucleus, nucleolus Chromosome, centromere. Cytoplasm {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9DB96}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites {ECO:0000250|UniProtKB:Q9DB96} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Neuroguidin is an EIF4E (MIM 133440)-binding protein thatinteracts with CPEB (MIM 607342) and functions as a translationalregulatory protein during development of the vertebrate nervoussystem (Jung et al., 2006 [PubMed 16705177]).
References
Sihn, C.R., et al. Genes Cells 13(8):787-796(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Jung, M.Y., et al. Mol. Cell. Biol. 26(11):4277-4287(2006)Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
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