|Other Names||Epidermal retinol dehydrogenase 2, EPHD-2, RDH-E2, Retinal short-chain dehydrogenase reductase 2, retSDR2, Short-chain dehydrogenase/reductase family 16C member 5, SDR16C5, RDHE2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients. Detected in fetal kidney, skin and lung.|
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Provided below are standard protocols that you may find useful for product applications.
RDHE2 belongs to a family of short-chain alcoholdehydrogenases/reductases that catalyze the first and rate-limitingstep that generates retinaldehyde from retinol (Matsuzaka et al.,2002 [PubMed 12372410]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Takahashi, Y., et al. Biochem. J. 419(1):113-122(2009)Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :Lee, S.A., et al. Chem. Biol. Interact. 178 (1-3), 182-187 (2009) :
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