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KRT7 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08729 |
|---|---|
| Clone Names | 100427107 |
| Gene ID | 3855 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7, KRT7, SCL |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KRT7 |
|---|---|
| Synonyms | SCL |
| Function | Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thekeratin gene family. The type II cytokeratins consist of basic orneutral proteins which are arranged in pairs of heterotypic keratinchains coexpressed during differentiation of simple and stratifiedepithelial tissues. This type II cytokeratin is specificallyexpressed in the simple epithelia lining the cavities of theinternal organs and in the gland ducts and blood vessels. The genesencoding the type II cytokeratins are clustered in a region ofchromosome 12q12-q13. Alternative splicing may result in severaltranscript variants; however, not all variants have been fullydescribed.
References
Tsai, Y.Y., et al. Acta Derm. Venereol. 90(4):438-439(2010)Stewart, C.J., et al. Histopathology 57(1):46-54(2010)Nagashio, R., et al. Pathol. Int. 60(2):71-77(2010)Sano, M., et al. Int. J. Oncol. 36(2):321-330(2010)Park, S., et al. Pathology 41(7):640-644(2009)
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