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GLUT2 (SLC2A2) Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11168 |
|---|---|
| Clone Names | 70716062 |
| Gene ID | 6514 |
|---|---|
| Other Names | Solute carrier family 2, facilitated glucose transporter member 2, Glucose transporter type 2, liver, GLUT-2, SLC2A2, GLUT2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1489a was selected from the N-term region of human SLC2A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC2A2 (HGNC:11006) |
|---|---|
| Function | Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Liver, insulin-producing beta cell, small intestine and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor.
References
Freitas,H.S., Nephron Physiol 105 (3), P42-P51 (2007)Laukkanen,O., Diabetes 54 (7), 2256-2260 (2005)Roncero,I., J. Neurochem. 88 (5), 1203-1210 (2004)
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