|Other Names||Segment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2, DVL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity)|
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This gene encodes a member of the dishevelled (dsh)protein family. The vertebrate dsh proteins have approximately 40%amino acid sequence similarity with Drosophila dsh. This geneencodes a 90-kD protein that undergoes posttranslationalphosphorylation to form a 95-kD cytoplasmic protein, which may playa role in the signal transduction pathway mediated by multiple Wntproteins. The mechanisms of dishevelled function in Wnt signalingare likely to be conserved among metazoans.
Inkster, B., et al. Neuroimage 53(3):908-917(2010)Kikuchi, K., et al. EMBO J. 29(20):3470-3483(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gao, C., et al. Nat. Cell Biol. 12(8):781-790(2010)Gnad, T., et al. Mol. Cancer 9, 31 (2010) :
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