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DVL2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O14641 |
|---|---|
| Clone Names | 100525320 |
| Gene ID | 1856 |
|---|---|
| Other Names | Segment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2, DVL2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DVL2 |
|---|---|
| Function | Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q60838}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q60838}; Cytoplasmic side {ECO:0000250|UniProtKB:Q60838}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q60838}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q60838}. Nucleus Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136) {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:25805136} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the dishevelled (dsh)protein family. The vertebrate dsh proteins have approximately 40%amino acid sequence similarity with Drosophila dsh. This geneencodes a 90-kD protein that undergoes posttranslationalphosphorylation to form a 95-kD cytoplasmic protein, which may playa role in the signal transduction pathway mediated by multiple Wntproteins. The mechanisms of dishevelled function in Wnt signalingare likely to be conserved among metazoans.
References
Inkster, B., et al. Neuroimage 53(3):908-917(2010)Kikuchi, K., et al. EMBO J. 29(20):3470-3483(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gao, C., et al. Nat. Cell Biol. 12(8):781-790(2010)Gnad, T., et al. Mol. Cancer 9, 31 (2010) :
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