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RBM5 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P52756
Clone Names 100525323
Peptide ID 100525323
Additional Information
Gene ID 10181
Other Names RNA-binding protein 5, Protein G15, Putative tumor suppressor LUCA15, RNA-binding motif protein 5, Renal carcinoma antigen NY-REN-9, RBM5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBM5
Function Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Cellular Location Nucleus.
Tissue Location Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines
Research Areas
Citations (0)

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Background

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

References

Sugliani, M., et al. Plant Cell 22(6):1936-1946(2010)Rintala-Maki, N.D., et al. Gene 445 (1-2), 7-16 (2009) :Kotlajich, M.V., et al. Mol. Cell 32(2):162-164(2008)Fushimi, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105(41):15708-15713(2008)Bonnal, S., et al. Mol. Cell 32(1):81-95(2008)

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$ 80.00
Cat# BP14901c
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