|Other Names||Mothers against decapentaplegic homolog 9, MAD homolog 9, Mothers against DPP homolog 9, Madh6, SMAD family member 9, SMAD 9, Smad9, SMAD9, MADH6, MADH9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).|
|Cellular Location||Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand Migration to the nucleus when complexed with SMAD4 (By similarity).|
|Tissue Location||Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SMADfamily, which transduces signals from TGF-beta family members. Theencoded protein is activated by bone morphogenetic proteins andinteracts with SMAD4. Two transcript variants encoding differentisoforms have been found for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Liu, Y., et al. FASEB J. 23(7):2299-2306(2009)Su, D., et al. J. Biol. Chem. 284(18):12153-12164(2009)Shintani, M., et al. J. Med. Genet. 46(5):331-337(2009)Hoover, L.L., et al. Sci Signal 1 (46), PE48 (2008) :
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