Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
CCT4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P50991 |
|---|---|
| Clone Names | 100528128 |
| Gene ID | 10575 |
|---|---|
| Other Names | T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta, Stimulator of TAR RNA-binding, CCT4, CCTD, SRB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCT4 |
|---|---|
| Synonyms | CCTD, SRB |
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). |
| Cellular Location | Cytoplasm. Melanosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P80315} Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The chaperonin containing TCP1 (MIM 186980) complex (CCT),also called the TCP1 ring complex, consists of 2 back-to-backrings, each containing 8 unique but homologous subunits, such asCCT4. CCT assists the folding of newly translated polypeptidesubstrates through multiple rounds of ATP-driven release andrebinding of partially folded intermediate forms. Substrates of CCTinclude the cytoskeletal proteins actin (see MIM 102560) andtubulin (see MIM 191130), as well as alpha-transducin (MIM 139330)(Won et al., 1998 [PubMed 9819444]).
References
Mukherjee, K., et al. BMC Evol. Biol. 10, 64 (2010) :Zebol, J.R., et al. Int. J. Biochem. Cell Biol. 41(4):822-827(2009)Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Imai, Y., et al. J. Biol. Chem. 278(51):51901-51910(2003)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
