|Other Names||Pre-mRNA-splicing factor RBM22, RNA-binding motif protein 22, Zinc finger CCCH domain-containing protein 16, RBM22, ZC3H16|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.|
|Cellular Location||Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an RNA binding protein. The encodedprotein may play a role in cell division and may be involved inpre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7,9, 13, 16, 18, and X.
Krebs, J. Biochim. Biophys. Acta 1793(6):979-984(2009)Satoh, J., et al. Neuropathol. Appl. Neurobiol. 35(1):16-35(2009)He, F., et al. Genet. Mol. Res. 8(4):1466-1473(2009)Montaville, P., et al. Biochim. Biophys. Acta 1763(11):1335-1343(2006)Kittler, R., et al. Nature 432(7020):1036-1040(2004)
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