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RBM22 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NW64
Clone Names 100528167
Additional Information
Gene ID 55696
Other Names Pre-mRNA-splicing factor RBM22, RNA-binding motif protein 22, Zinc finger CCCH domain-containing protein 16, RBM22, ZC3H16
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBM22
Synonyms ZC3H16
Function Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem- loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
Cellular Location Nucleus. Cytoplasm Note=Nearly exclusively nuclear. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.
Research Areas
Citations (0)
citation

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Background

This gene encodes an RNA binding protein. The encodedprotein may play a role in cell division and may be involved inpre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7,9, 13, 16, 18, and X.

References

Krebs, J. Biochim. Biophys. Acta 1793(6):979-984(2009)Satoh, J., et al. Neuropathol. Appl. Neurobiol. 35(1):16-35(2009)He, F., et al. Genet. Mol. Res. 8(4):1466-1473(2009)Montaville, P., et al. Biochim. Biophys. Acta 1763(11):1335-1343(2006)Kittler, R., et al. Nature 432(7020):1036-1040(2004)

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$ 277.78
Cat# BP14906c
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