|Other Names||Plakophilin-3, PKP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in junctional plaques.|
|Cellular Location||Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes|
|Tissue Location||Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.|
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This gene encodes a member of the arm-repeat (armadillo)and plakophilin gene families. Plakophilin proteins containnumerous armadillo repeats, localize to cell desmosomes and nuclei,and participate in linking cadherins to intermediate filaments inthe cytoskeleton. This protein may act in cellulardesmosome-dependent adhesion and signaling pathways. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Valladares-Ayerbes, M., et al. Cancer Epidemiol. Biomarkers Prev. 19(6):1432-1440(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kundu, S.T., et al. Int. J. Cancer 123(10):2303-2314(2008)Valladares-Ayerbes, M., et al. Cancer Detect. Prev. 32(3):236-250(2008)
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