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SECISBP2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96T21 |
|---|---|
| Clone Names | 100528089 |
| Gene ID | 79048 |
|---|---|
| Other Names | Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SECISBP2 {ECO:0000303|PubMed:19004874, ECO:0000312|HGNC:HGNC:30972} |
|---|---|
| Function | mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:35709277). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (PubMed:35709277). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (PubMed:35709277). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl- tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (PubMed:35709277). |
| Cellular Location | [Isoform 1]: Nucleus. |
| Tissue Location | Expressed at high levels in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The incorporation of selenocysteine into a proteinrequires the concerted action of an mRNA element called a secinsertion sequence (SECIS), a selenocysteine-specific translationelongation factor and a SECIS binding protein. With these elementsin place, a UGA codon can be decoded as selenocysteine. The genedescribed in this record encodes a nuclear protein that functionsas a SECIS binding protein. Mutations in this gene have beenassociated with a reduction in activity of a specific thyroxinedeiodinase, a selenocysteine-containing enzyme, and abnormalthyroid hormone metabolism.
References
Meplan, C., et al. Carcinogenesis 31(6):1074-1079(2010)Papp, L.V., et al. Antioxid. Redox Signal. 12(7):797-808(2010)Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94(10):4003-4009(2009)Olieric, V., et al. Biochimie 91(8):1003-1009(2009)Schomburg, L., et al. Thyroid 19(3):277-281(2009)
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