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SECISBP2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96T21
Clone Names 100528089
Peptide ID 100528089
Additional Information
Gene ID 79048
Other Names Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SECISBP2
Synonyms SBP2
Function Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Cellular Location Isoform 1: Nucleus.
Tissue Location Expressed at high levels in testis.
Research Areas
Citations (0)

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Background

The incorporation of selenocysteine into a proteinrequires the concerted action of an mRNA element called a secinsertion sequence (SECIS), a selenocysteine-specific translationelongation factor and a SECIS binding protein. With these elementsin place, a UGA codon can be decoded as selenocysteine. The genedescribed in this record encodes a nuclear protein that functionsas a SECIS binding protein. Mutations in this gene have beenassociated with a reduction in activity of a specific thyroxinedeiodinase, a selenocysteine-containing enzyme, and abnormalthyroid hormone metabolism.

References

Meplan, C., et al. Carcinogenesis 31(6):1074-1079(2010)Papp, L.V., et al. Antioxid. Redox Signal. 12(7):797-808(2010)Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94(10):4003-4009(2009)Olieric, V., et al. Biochimie 91(8):1003-1009(2009)Schomburg, L., et al. Thyroid 19(3):277-281(2009)

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$ 80.00
Cat# BP14908c
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