|Other Names||Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.|
|Cellular Location||Isoform 1: Nucleus.|
|Tissue Location||Expressed at high levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
The incorporation of selenocysteine into a proteinrequires the concerted action of an mRNA element called a secinsertion sequence (SECIS), a selenocysteine-specific translationelongation factor and a SECIS binding protein. With these elementsin place, a UGA codon can be decoded as selenocysteine. The genedescribed in this record encodes a nuclear protein that functionsas a SECIS binding protein. Mutations in this gene have beenassociated with a reduction in activity of a specific thyroxinedeiodinase, a selenocysteine-containing enzyme, and abnormalthyroid hormone metabolism.
Meplan, C., et al. Carcinogenesis 31(6):1074-1079(2010)Papp, L.V., et al. Antioxid. Redox Signal. 12(7):797-808(2010)Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94(10):4003-4009(2009)Olieric, V., et al. Biochimie 91(8):1003-1009(2009)Schomburg, L., et al. Thyroid 19(3):277-281(2009)
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