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ABCG2 (BCRP) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UNQ0
Clone Names 70716019
Peptide ID 70716019
Additional Information
Gene ID 9429
Other Names ATP-binding cassette sub-family G member 2, Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCG2, ABCP, BCRP, BCRP1, MXR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1490c was selected from the Center region of human ABCG2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCG2
Function High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Cellular Location Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein
Tissue Location Highly expressed in placenta. Low expression in small intestine, liver and colon.
Research Areas
Citations (0)

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ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.


Xie,Y., J. Biol. Chem. 283 (6), 3349-3356 (2008)Tamura,A., Drug Metab. Pharmacokinet. 22 (6), 428-440 (2007)

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$ 80.00
Cat# BP1490c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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