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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P60468 |
|---|---|
| Clone Names | 100528092 |
| Peptide ID | 100528092 |
| Gene ID | 10952 |
|---|---|
| Other Names | Protein transport protein Sec61 subunit beta, SEC61B |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEC61B |
|---|---|
| Function | Necessary for protein translocation in the endoplasmic reticulum. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Sec61 complex is the central component of the proteintranslocation apparatus of the endoplasmic reticulum (ER) membrane.Oligomers of the Sec61 complex form a transmembrane channel whereproteins are translocated across and integrated into the ERmembrane. This complex consists of three membrane proteins- alpha,beta, and gamma. This gene encodes the beta-subunit protein. TheSec61 subunits are also observed in the post-ER compartment,suggesting that these proteins can escape the ER and recycle back.There is evidence for multiple polyadenylated sites for thistranscript.
References
Liao, H.J., et al. Cancer Res. 69(15):6179-6183(2009)Wang, B., et al. Cell 133(6):1080-1092(2008)Liao, H.J., et al. Mol. Biol. Cell 18(3):1064-1072(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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