|Other Names||Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18, RNF110, ZNF144|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MEL18, RNF110, ZNF144|
|Function||Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).|
|Tissue Location||Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle|
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The protein encoded by this gene contains a RING fingermotif and is similar to the polycomb group (PcG) gene products. PcGgene products form complexes via protein-protein interaction andmaintain the transcription repression of genes involved inembryogenesis, cell cycles, and tumorigenesis. This protein wasshown to act as a negative regulator of transcription and has tumorsuppressor activity. The expression of this gene was detected invarious tumor cells, but is limited in neural organs in normaltissues. Knockout studies in mice suggested that this protein maynegatively regulate the expression of different cytokines,chemokines, and chemokine receptors, and thus plays an importantrole in lymphocyte differentiation and migration, as well as inimmune responses.
Jung, J.H., et al. Biochem. Biophys. Res. Commun. 400(4):523-530(2010)Zhang, X.W., et al. Mol. Cancer 9, 40 (2010) :Wang, W., et al. Int. J. Cancer 125(12):2836-2843(2009)Zhang, J., et al. Biochem. Biophys. Res. Commun. 375(2):252-255(2008)Elderkin, S., et al. Mol. Cell 28(1):107-120(2007)
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