|Other Names||Actin, alpha cardiac muscle 1, Alpha-cardiac actin, ACTC1, ACTC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1491a was selected from the N-term region of human ACTB/ACTC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. ACTB/ACTC are nonmuscle cytoskeletal actins and major constituents of the contractile apparatus. Defects in ACTB are a cause of juvenile-onset dystonia. Defects in ACTC have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).
Villebeck,L., Biochemistry 46 (44), 12639-12647 (2007)Avizienyte,E., Exp. Cell Res. 313 (15), 3175-3188 (2007)Bouldin,A.A., Muscle Nerve 35 (2), 254-258 (2007)
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