|Other Names||Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the beta subunit of the glycinereceptor, which is a pentamer composed of alpha and beta subunits.The receptor functions as a neurotransmitter-gated ion channel,which produces hyperpolarization via increased chloride conductancedue to the binding of glycine to the receptor. Mutations in thisgene cause startle disease, also known as hereditary hyperekplexiaor congenital stiff-person syndrome, a disease characterized bymuscular rigidity. Alternative splicing results in multipletranscript variants.
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380(4):277-291(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :Ahrens, J., et al. Pharmacology 83(4):217-222(2009)
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