|Other Names||Putative helicase MOV-10, Moloney leukemia virus 10 protein, MOV10, KIAA1631|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC.|
|Cellular Location||Cytoplasm, P-body|
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Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
El Messaoudi-Aubert, S., et al. Nat. Struct. Mol. Biol. 17(7):862-868(2010)Furtak, V., et al. PLoS ONE 5 (2), E9081 (2010) :Nakano, M., et al. Biochem. Biophys. Res. Commun. 388(2):328-332(2009)Haussecker, D., et al. Nat. Struct. Mol. Biol. 15(7):714-721(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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