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S100B/S-100 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P04271
Clone Names 101229016
Peptide ID 101229016
Additional Information
Gene ID 6285
Other Names Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B, S100B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name S100B
Function Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Cellular Location Cytoplasm. Nucleus
Tissue Location Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21; however, this gene islocated at 21q22.3. This protein may function in Neurite extension,proliferation of melanoma cells, stimulation of Ca2+ fluxes,inhibition of PKC-mediated phosphorylation, astrocytosis and axonalproliferation, and inhibition of microtubule assembly. Chromosomalrearrangements and altered expression of this gene have beenimplicated in several neurological, neoplastic, and other types ofdiseases, including Alzheimer's disease, Down's syndrome, epilepsy,amyotrophic lateral sclerosis, melanoma, and type I diabetes.


Sahoo, N., et al. FEBS Lett. 584(18):3896-3900(2010)Lin, J., et al. J. Biol. Chem. 285(35):27487-27498(2010)van Dieck, J., et al. FEBS Lett. 584(15):3269-3274(2010)Egberts, F., et al. Anticancer Res. 30(5):1799-1805(2010)Boutsikou, T., et al. Mediators Inflamm. 2010, 790605 (2010) :

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$ 80.00
Cat# BP14936c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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