|Other Names||Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.|
|Tissue Location||GE-25 is found in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thechromogranin/secretogranin family of neuroendocrine secretoryproteins. It is found in secretory vesicles of neurons andendocrine cells. This gene product is a precursor to threebiologically active peptides; vasostatin, pancreastatin, andparastatin. These peptides act as autocrine or paracrine negativemodulators of the neuroendocrine system. Other peptides, includingchromostatin, beta-granin, WE-14 and GE-25, are also derived fromthe full-length protein. However, biological activities for thesemolecules have not been shown.
Ezzi, S.A., et al. J. Neurochem. 115(5):1102-1111(2010)Ma, Z., et al. J. Urol. 184(3):1182-1188(2010)Ramella, R., et al. J. Cell. Biochem. 110(1):70-79(2010)Dag, E., et al. Peptides 31(5):932-937(2010)Xie, Y.Q., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(12):1081-1084(2009)
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