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CD4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01730 |
|---|---|
| Clone Names | 70730005 |
| Gene ID | 920 |
|---|---|
| Other Names | T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, CD4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CD4 |
|---|---|
| Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T- helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV- 1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum |
| Tissue Location | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a membrane glycoprotein of T lymphocytesthat interacts with major histocompatibility complex class IIantigenes and is also a receptor for the human immunodeficiencyvirus. This gene is expressed not only in T lymphocytes, but alsoin B cells, macrophages, and granulocytes. It is also expressed inspecific regions of the brain. The protein functions to initiate oraugment the early phase of T-cell activation, and may function asan important mediator of indirect neuronal damage in infectious andimmune-mediated diseases of the central nervous system. Multiplealternatively spliced transcript variants encoding differentisoforms have been identified in this gene.
References
Pourgheysari, B., et al. Blood 116(16):2968-2974(2010)Rudd, C.E., et al. J. Immunol. 185(5):2645-2649(2010)Ammirati, E., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1832-1841(2010)Schenkel, J.M., et al. J. Immunol. 185(4):2013-2019(2010)Lee, K.M., et al. Am. J. Hematol. 85(8):560-563(2010)
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