|Other Names||Histone deacetylase 11, HD11, HDAC11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|
|Cellular Location||Nucleus. Note=Predominantly nuclear.|
|Tissue Location||Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis|
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This gene encodes a class IV histone deacetylase. Theencoded protein is localized to the nucleus and may be involved inregulating the expression of interleukin 10. Alternative splicingresults in multiple transcript variants.
Janssen, C., et al. J. Neuropathol. Exp. Neurol. 69(6):573-581(2010)Glozak, M.A., et al. J. Biol. Chem. 284(17):11446-11453(2009)Georgopoulos, K. Nat. Immunol. 10(1):13-14(2009)Villagra, A., et al. Nat. Immunol. 10(1):92-100(2009)Fournel, M., et al. Mol. Cancer Ther. 7(4):759-768(2008)
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