|Other Names||Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, ACTN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle|
|Tissue Location||Expressed in both skeletal and cardiac muscle.|
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Alpha actinins belong to the spectrin gene superfamilywhich represents a diverse group of cytoskeletal proteins,including the alpha and beta spectrins and dystrophins. Alphaactinin is an actin-binding protein with multiple roles indifferent cell types. In nonmuscle cells, the cytoskeletal isoformis found along microfilament bundles and adherens-type junctions,where it is involved in binding actin to the membrane. In contrast,skeletal, cardiac, and smooth muscle isoforms are localized to theZ-disc and analogous dense bodies, where they help anchor themyofibrillar actin filaments. This gene encodes a muscle-specific,alpha actinin isoform that is expressed in both skeletal andcardiac muscles.
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Chiu, C., et al. J. Am. Coll. Cardiol. 55(11):1127-1135(2010)
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