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ACTN2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35609 |
|---|---|
| Clone Names | 100525130 |
| Gene ID | 88 |
|---|---|
| Other Names | Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, ACTN2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ACTN2 |
|---|---|
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Cellular Location | Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle |
| Tissue Location | Expressed in both skeletal and cardiac muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Alpha actinins belong to the spectrin gene superfamilywhich represents a diverse group of cytoskeletal proteins,including the alpha and beta spectrins and dystrophins. Alphaactinin is an actin-binding protein with multiple roles indifferent cell types. In nonmuscle cells, the cytoskeletal isoformis found along microfilament bundles and adherens-type junctions,where it is involved in binding actin to the membrane. In contrast,skeletal, cardiac, and smooth muscle isoforms are localized to theZ-disc and analogous dense bodies, where they help anchor themyofibrillar actin filaments. This gene encodes a muscle-specific,alpha actinin isoform that is expressed in both skeletal andcardiac muscles.
References
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Chiu, C., et al. J. Am. Coll. Cardiol. 55(11):1127-1135(2010)
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