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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Erbb2 Antibody (Center) Blocking Peptide   

Mouse Erbb2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P70424
Clone Names 110316154
Peptide ID 110316154
Additional Information
Gene ID 13866
Other Names Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Erbb2
Synonyms Kiaa3023, Neu
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus
Tissue Location Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers
Research Areas
Citations (0)

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Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Binds to the 5'-TCAAATTC-3' sequence in the MT-CO2 promoter and activates its transcription (By similarity).


Cabodi, S., et al. FASEB J. 24(10):3796-3808(2010)Johnson, E., et al. J. Biol. Chem. 285(38):29491-29501(2010)Huck, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15559-15564(2010)Chuang, T.D., et al. J. Biol. Chem. 285(31):23598-23606(2010)Simeone, L., et al. J. Neurosci. 30(19):6620-6634(2010)

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$ 80.00
Cat# BP14954c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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