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Mouse Map3k12 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q60700 |
|---|---|
| Clone Names | 110316226 |
| Gene ID | 26404 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 12, Dual leucine zipper bearing kinase, DLK, Leucine-zipper protein kinase, ZPK, MAPK-upstream kinase, MUK, Mixed lineage kinase, Map3k12, Zpk |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Map3k12 |
|---|---|
| Synonyms | Zpk |
| Function | Protein kinase which is part of a non-canonical MAPK signaling pathway (PubMed:7983011, PubMed:8663324, PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. |
| Cellular Location | Cytoplasm. Cell membrane. Note=Behaves essentially as an integral membrane protein. |
| Tissue Location | Within the nervous system, predominantly expressed in neurons and enriched in synaptic terminals (PubMed:8663324) Expressed in brain, kidney, lung, heart, testis, gastrointestinal tract, stomach, liver and pancreas (PubMed:8769565, PubMed:7983011) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Map3k12 may be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
References
Hirose, Y., et al. Exp. Cell Res. 315(15):2648-2657(2009)Saiga, T., et al. Mol. Cell. Biol. 29(13):3529-3543(2009)Itoh, A., et al. Biochem. Biophys. Res. Commun. 383(2):258-262(2009)Daviau, A., et al. Cell. Signal. 21(4):577-587(2009)Couture, J.P., et al. PLoS ONE 4 (3), E4743 (2009) :
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