|Other Names||Mitogen-activated protein kinase kinase kinase 12, Dual leucine zipper bearing kinase, DLK, Leucine-zipper protein kinase, ZPK, MAPK-upstream kinase, MUK, Mixed lineage kinase, Map3k12, Zpk|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Expressed in brain, kidney, lung, heart, testis, gastrointestinal tract, stomach, liver and pancreas Within the nervous system, predominantly expressed in neurons and enriched in synaptic terminals|
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Map3k12 may be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Hirose, Y., et al. Exp. Cell Res. 315(15):2648-2657(2009)Saiga, T., et al. Mol. Cell. Biol. 29(13):3529-3543(2009)Itoh, A., et al. Biochem. Biophys. Res. Commun. 383(2):258-262(2009)Daviau, A., et al. Cell. Signal. 21(4):577-587(2009)Couture, J.P., et al. PLoS ONE 4 (3), E4743 (2009) :
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