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SMURF1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HCE7
Clone Names 100507126
Peptide ID 100507126
Additional Information
Gene ID 57154
Other Names E3 ubiquitin-protein ligase SMURF1, hSMURF1, 632-, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1, SMURF1, KIAA1625
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMURF1
Synonyms KIAA1625
Function E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in melanocytes (PubMed:23999003).
Research Areas
Citations (0)

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Background

This gene encodes a ubiquitin ligase that is specific forreceptor-regulated SMAD proteins in the bone morphogenetic protein(BMP) pathway. A similar protein in Xenopus is involved inembryonic pattern formation. Alternative splicing results inmultiple transcript variants encoding different isoforms. Anadditional transcript variant has been identified, but its fulllength sequence has not been determined.

References

Li, S., et al. Mol. Cell. Biochem. 338 (1-2), 11-17 (2010) :Franke, A., et al. Nat. Genet. 42(4):292-294(2010)Alarcon, C., et al. Cell 139(4):757-769(2009)Crose, L.E., et al. J. Biol. Chem. 284(20):13301-13305(2009)Narimatsu, M., et al. Cell 137(2):295-307(2009)

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$ 80.00
Cat# BP14957c
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