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SMURF1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HCE7 |
|---|---|
| Clone Names | 100507126 |
| Gene ID | 57154 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase SMURF1, hSMURF1, 632-, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1, SMURF1, KIAA1625 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SMURF1 |
|---|---|
| Synonyms | KIAA1625 |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side |
| Tissue Location | Expressed in melanocytes (PubMed:23999003). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a ubiquitin ligase that is specific forreceptor-regulated SMAD proteins in the bone morphogenetic protein(BMP) pathway. A similar protein in Xenopus is involved inembryonic pattern formation. Alternative splicing results inmultiple transcript variants encoding different isoforms. Anadditional transcript variant has been identified, but its fulllength sequence has not been determined.
References
Li, S., et al. Mol. Cell. Biochem. 338 (1-2), 11-17 (2010) :Franke, A., et al. Nat. Genet. 42(4):292-294(2010)Alarcon, C., et al. Cell 139(4):757-769(2009)Crose, L.E., et al. J. Biol. Chem. 284(20):13301-13305(2009)Narimatsu, M., et al. Cell 137(2):295-307(2009)
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