|Other Names||cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane|
|Tissue Location||Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible|
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Provided below are standard protocols that you may find useful for product applications.
cAMP is a signaling molecule important for a variety ofcellular functions. cAMP exerts its effects by activating thecAMP-dependent protein kinase, which transduces the signal throughphosphorylation of different target proteins. The inactive kinaseholoenzyme is a tetramer composed of two regulatory and twocatalytic subunits. cAMP causes the dissociation of the inactiveholoenzyme into a dimer of regulatory subunits bound to four cAMPand two free monomeric catalytic subunits. Four differentregulatory subunits and three catalytic subunits have beenidentified in humans. The protein encoded by this gene is one ofthe regulatory subunits. This subunit can be phosphorylated by theactivated catalytic subunit. This subunit has been shown tointeract with and suppress the transcriptional activity of the cAMPresponsive element binding protein 1 (CREB1) in activated T cells.Knockout studies in mice suggest that this subunit may play animportant role in regulating energy balance and adiposity. Thestudies also suggest that this subunit may mediate the geneinduction and cataleptic behavior induced by haloperidol. [providedby RefSeq].
Liu, Y.J., et al. Obesity (Silver Spring) (2010) In press :Adkins, D.E., et al. Mol. Psychiatry (2010) In press :Islam, A., et al. J. Biol. Chem. 283(37):25364-25371(2008)Ji, Z., et al. J. Biol. Chem. 283(32):21920-21925(2008)Vincent-Dejean, C., et al. Eur. J. Endocrinol. 158(6):829-839(2008)
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