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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Map4k2 Antibody (Center) Blocking Peptide   

Mouse Map4k2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q61161
Clone Names 110316239
Peptide ID 110316239
Additional Information
Gene ID 26412
Other Names Mitogen-activated protein kinase kinase kinase kinase 2, Germinal center kinase, GCK, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting protein, Map4k2, Rab8ip
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Map4k2
Synonyms Rab8ip
Function Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN),or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion.
Cellular Location Cytoplasm. Basolateral cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein
Research Areas
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Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.


Zhong, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(11):4372-4377(2009)Ren, M., et al. Proc. Natl. Acad. Sci. U.S.A. 93(10):5151-5155(1996)

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$ 80.00
Cat# BP14965c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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