|Other Names||LIM/homeobox protein Lhx6, LIM homeobox protein 6, LIM/homeobox protein Lhx61, LHX6, LHX61|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).|
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This gene encodes a member of a large protein family thatcontains the LIM domain, a unique cysteine-rich zinc-bindingdomain. The encoded protein may function as a transcriptionalregulator and may be involved in the control of differentiation anddevelopment of neural and lymphoid cells. Two alternatively splicedtranscript variants encoding distinct isoforms have been describedfor this gene. Alternatively spliced transcript variants have beenidentified, but their biological validity has not been determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jung, S., et al. Oncol. Rep. 23(6):1675-1682(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Estecio, M.R., et al. Oncogene 25(36):5018-5026(2006)Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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