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CD4 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P01730
Clone Names 70730005
Peptide ID 70730005
Additional Information
Gene ID 920
Other Names T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, CD4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1496a was selected from the N-term region of human CD4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD4
Function Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Cellular Location Cell membrane; Single-pass type I membrane protein Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum
Research Areas
Citations (0)

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CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes (helper/inducer T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.


Garron,M.L., J. Mol. Biol. 375 (5), 1320-1328 (2008)Rychert,J., J. Acquir. Immune Defic. Syndr. 46 (3), 261-267 (2007)

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$ 80.00
Cat# BP1496a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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