|Other Names||Histamine H2 receptor, H2R, HH2R, Gastric receptor I, HRH2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Histamine is a ubiquitous messenger molecule released frommast cells, enterochromaffin-like cells, and neurons. Its variousactions are mediated by histamine receptors H1, H2, H3 and H4.Histamine receptor H2 belongs to the family 1 of G protein-coupledreceptors. It is an integral membrane protein and stimulatesgastric acid secretion. It also regulates gastrointestinal motilityand intestinal secretion and is thought to be involved inregulating cell growth and differentiation. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Szukiewicz, D., et al. Inflamm. Res. 59 SUPPL 2, S205-S207 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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