|Other Names||Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PR61alpha, PP2A B subunit isoform R5-alpha, PPP2R5A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|
|Cellular Location||Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.|
|Tissue Location||Widely expressed with the highest expression in heart and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the phosphatase 2Aregulatory subunit B family. Protein phosphatase 2A is one of thefour major Ser/Thr phosphatases, and it is implicated in thenegative control of cell growth and division. It consists of acommon heteromeric core enzyme, which is composed of a catalyticsubunit and a constant regulatory subunit, that associates with avariety of regulatory subunits. The B regulatory subunit mightmodulate substrate selectivity and catalytic activity. This geneencodes an alpha isoform of the regulatory subunit B56 subfamily.
Flegg, C.P., et al. J. Biol. Chem. 285(24):18144-18154(2010)Freeman, A.K., et al. Cell Cycle 9(4):736-747(2010)Reece, K.M., et al. Biochem. Biophys. Res. Commun. 386(4):582-587(2009)Li, H., et al. Mol. Cell. Biol. 29(3):919-928(2009)Ruvolo, V.R., et al. J. Biol. Chem. 283(51):35474-35485(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.