|Other Names||Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PR61alpha, PP2A B subunit isoform R5-alpha, PPP2R5A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|
|Cellular Location||Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.|
|Tissue Location||Widely expressed with the highest expression in heart and skeletal muscle|
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The product of this gene belongs to the phosphatase 2Aregulatory subunit B family. Protein phosphatase 2A is one of thefour major Ser/Thr phosphatases, and it is implicated in thenegative control of cell growth and division. It consists of acommon heteromeric core enzyme, which is composed of a catalyticsubunit and a constant regulatory subunit, that associates with avariety of regulatory subunits. The B regulatory subunit mightmodulate substrate selectivity and catalytic activity. This geneencodes an alpha isoform of the regulatory subunit B56 subfamily.
Flegg, C.P., et al. J. Biol. Chem. 285(24):18144-18154(2010)Freeman, A.K., et al. Cell Cycle 9(4):736-747(2010)Reece, K.M., et al. Biochem. Biophys. Res. Commun. 386(4):582-587(2009)Li, H., et al. Mol. Cell. Biol. 29(3):919-928(2009)Ruvolo, V.R., et al. J. Biol. Chem. 283(51):35474-35485(2008)
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