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MXI1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P50539
Clone Names 100525212
Peptide ID 100525212
Additional Information
Gene ID 4601
Other Names Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MXI1
Synonyms BHLHC11
Function Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
Cellular Location Nucleus.
Tissue Location High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle
Research Areas
Citations (0)

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Expression of the c-myc gene, which produces an oncogenictranscription factor, is tightly regulated in normal cells but isfrequently deregulated in human cancers. The protein encoded bythis gene is a transcriptional repressor thought to negativelyregulate MYC function, and is therefore a potential tumorsuppressor. This protein inhibits the transcriptional activity ofMYC by competing for MAX, another basic helix-loop-helix proteinthat binds to MYC and is required for its function. Defects in thisgene are frequently found in patients with prostate tumors. Threealternatively spliced transcripts encoding different isoforms havebeen described. Additional alternatively spliced transcripts mayexist but the products of these transcripts have not been verifiedexperimentally.


Lofstedt, T., et al. Exp. Cell Res. 315(11):1924-1936(2009)Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)Tsao, C.C., et al. Cancer Biol. Ther. 7(10):1619-1627(2008)Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)Dugast-Darzacq, C., et al. FEBS J. 274(17):4643-4653(2007)

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$ 80.00
Cat# BP14974c
Availability: In Stock
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