TBX3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15119 |
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Clone Names | 100525279 |
Gene ID | 6926 |
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Other Names | T-box transcription factor TBX3, T-box protein 3, TBX3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TBX3 |
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Function | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'- TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. |
Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of a phylogenetically conservedfamily of genes that share a common DNA-binding domain, the T-box.T-box genes encode transcription factors involved in the regulationof developmental processes. This protein is a transcriptionalrepressor and is thought to play a role in the anterior/posterioraxis of the tetrapod forelimb. Mutations in this gene causeulnar-mammary syndrome, affecting limb, apocrine gland, tooth,hair, and genital development. Alternative splicing of this generesults in three transcript variants encoding different isoforms;however, the full length nature of one variant has not beendetermined.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)Christoffels, V.M., et al. Circ. Res. 106(2):240-254(2010)Pfeufer, A., et al. Nat. Genet. 42(2):153-159(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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