|Other Names||COP9 signalosome complex subunit 8, SGN8, Signalosome subunit 8, COP9 homolog, hCOP9, JAB1-containing signalosome subunit 8, COPS8, CSN8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|
|Cellular Location||Cytoplasm. Nucleus|
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The protein encoded by this gene is one of the eightsubunits of COP9 signalosome, a highly conserved protein complexthat functions as an important regulator in multiple signalingpathways. The structure and function of COP9 signalosome is similarto that of the 19S regulatory particle of 26S proteasome. COP9signalosome has been shown to interact with SCF-type E3 ubiquitinligases and act as a positive regulator of E3 ubiquitin ligases.Alternatively spliced transcript variants encoding distinctisoforms have been observed.
Enchev, R.I., et al. Structure 18(4):518-527(2010)Miyauchi, Y., et al. J. Biol. Chem. 283(24):16622-16631(2008)Schweitzer, K., et al. EMBO J. 26(6):1532-1541(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wang, Y., et al. FEBS Lett. 572 (1-3), 85-91 (2004) :
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